Ethanolamine → 4-Fluoro-N-(2-hydroxyethyl)benzenesulfonamide
Reaktionsgleichung
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[CH2:12]([CH2:14][NH2:15])[OH:13]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:15][CH2:14][CH2:12][OH:13])(=[O:10])=[O:9])=[CH:4][CH:3]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared according to the procedure of Intermediate 33 from 3.97 g (20 mmol) of 4-fluorobenzenesulfonyl chloride and 3.11 g (50 mmol) of ethanolamine, yielding 3.0 g of a white solid; m.p. 77-78° C.; MS (ES) m/z 219.8 (MH+); HRMS (EI) Calcd. for C8H10FNO3S (M+): 219.0366, Found: 219.0369.
Quellen und Nachweise
- ORD-Eintrag
- ord-ac12dfeaa76f4340b608541a144041c5
- Quelldatensatz
- uspto-grants-2002_09
- Patentnummer
- US06444685B1
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