Clarithromycin → Clarithromycin formate

Beteiligte Stoffe

Reaktionsschritte

A method of preparing Form II crystals of clarithromycin of formula (I) comprising the steps of: (a) treating clarithromycin with formic acid in an organic solvent to give crystalline clarithromycin formate of formula (II) and (b) neutralizing the clarithromycin formate with a base in a mixture of water and a water-miscible organic solvent:

Herkunft & Nachweise