5,12-Naphthacenedione → Doxorubicin

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	5,12-Naphthacenedione	HCID 14160	—
Edukt	Doxorubicin Hydrochloride	HCID 443939	—
Produkt	Doxorubicin	HCID 31703	—

Reaktionsschritte

Doxorubicin hydrochloride, 5,12-Naphthacenedione, (8s-cis)-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11 -trihydroxy-8-(hydroxyacetyl)-1-methoxy-hydrochloride (hydroxydaunorubicin hydrochloride, Adriamycin) is used in a wide antineoplastic spectrum. It binds to DNA and inhibits nucleic acid synthesis, inhibits mitosis and promotes chromosomal aberrations.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US06444872B1
Quelldatensatz	uspto-grants-2002_09
ORD ID	ord-3cbd80ce8cd84674aa1c2c0b9814bd84
Quellennotiz	uspto-grants-2002_09