Sulfuric Acid → 7-Chloro-4-methyl-8-nitroisoquinoline

HRID 127920

Reaktionsgleichung

Reaktionsgleichung von HRID 127920
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:12])=[CH:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[N+:18]([O-])([O-:20])=[O:19].[K+]>>[Cl:1][C:2]1[C:11]([N+:18]([O-:20])=[O:19])=[C:10]2[C:5]([C:6]([CH3:12])=[CH:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 3

HCID 1118Sulfuric Acid2×HCID 24434Potassium NitrateHCID 205232237-Chloro-4-methylisoquinoline

Produkt 1

HCID 205232187-Chloro-4-methyl-8-nitroisoquinoline

Versuchsvorschrift

A mixture of 17.7 g. (0.1 mole) of 7-chloro-4-methylisoquinoline and 100 ml. of concentrated sulfuric acid is treated with 10 g. (0.1 mole) of potassium nitrate dissolved in 150 ml. of concentrated sulfuric acid. The mixture is stirred for one hour, quenched on ice, made alkaline with ammonium hydroxide and filtered to yield 7-chloro-4-methyl-8-nitroisoquinoline.

Aufarbeitung

  1. additionA mixture of 17.7 g
  2. customquenched on ice
  3. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-a885dba6cb6a4d0f9161773f58b06d57
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04258049

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