Trifluoroacetic acid → HCID 59909816, Verbindung

HRID 1279855Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1279855
[Cl:1][C:2]1[CH:32]=[CH:31][C:5]([O:6][CH2:7][C:8]2[N:12]=[C:11]([C@H:13]([CH2:22][CH2:23][CH2:24][CH:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)[CH2:14][C:15]([O:17]C(C)(C)C)=[O:16])[O:10][N:9]=2)=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][C:8]2[N:12]=[C:11]([C@H:13]([CH2:22][CH2:23][CH2:24][CH:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)[CH2:14][C:15]([OH:17])=[O:16])[O:10][N:9]=2)=[CH:31][CH:32]=1

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 59909802HCID 59909802, Verbindung

Produkt 1

HCID 59909816HCID 59909816, VerbindungAusbeute 101 %

Versuchsvorschrift

tert-Butyl (3R)-3-{3-[(4-chlorophenoxy)methyl]-1,2,4-oxadiazol-5-yl}6-cyclohexylhexanoate (Preparation 56) (215 mg, 0.46 mmol) was treated with trifluoroacetic acid (5 ml) and the resulting mixture was stirred at room temperature under a nitrogen atmosphere for 4 hours. The solvent was removed under reduced pressure and the residue azeotroped from toluene to afford the title compound (189 mg).

Aufarbeitung

  1. customThe solvent was removed under reduced pressure
  2. customthe residue azeotroped from toluene

Quellen und Nachweise

ORD-Eintrag
ord-a939e69104da4b938bbd532c30cdf3c5
Quelldatensatz
uspto-grants-2002_09
Patentnummer
US06448278B2

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