4-Fluoroaniline → HCID 178418420, Verbindung

HRID 1280

Reaktionsgleichung

Reaktionsgleichung von HRID 1280
[CH3:1][C:2]1[C:19]([F:20])=[C:18]([F:21])[CH:17]=[C:16]([F:22])[C:3]=1[C:4]([C:6](=[CH:12]OCC)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].[F:23][C:24]1[CH:30]=[CH:29][C:27]([NH2:28])=[CH:26][CH:25]=1>>[CH3:1][C:2]1[C:19]([F:20])=[C:18]([F:21])[CH:17]=[C:16]([F:22])[C:3]=1[C:4]([C:6](=[CH:12][NH:28][C:27]1[CH:29]=[CH:30][C:24]([F:23])=[CH:25][CH:26]=1)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5]

Komponenten

3

Edukt 2

HCID 97314-FluoroanilineHCID 54242925Ethyl 2-(2,4,5-trifluoro-6-methylbenzoyl)-3-ethoxyacrylate

Produkt 1

HCID 178418420HCID 178418420, Verbindung

Versuchsvorschrift

Employing ethyl 2-(2-methyl-3,4,6-trifluorobenzoyl)-3-ethoxyacrylate (1.0 g) and p-fluoroaniline (0.39 g), the procedure of Reference Example 8 is repeated to give ethyl 2-(2-methyl-3,4,6-trifluorobenzoyl)-3-(4-fluorophenyl)aminoacrylate, which is then treated with 60% sodium hydride (0.15 g) as in Reference Example 9 to give ethyl 1-(4-fluorophenyl)-5-methyl-6,7-difluoro-1,4-dihydro-4- oxoquinoline-3-carboxylate (0.64 g), as white crystals (recrystallized from ethanol), m.p. 256°-259° C.

Quellen und Nachweise

ORD-Eintrag
ord-ca06de262c0c42b696248fd0b6d115dc
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05723648

Verknüpfte Notizen

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