Dichloromethane → HCID 23471631, Verbindung

Reaktionsgleichung

ClC1[CH:3]=[CH:4][C:5]([NH:16][CH3:17])=[C:6]([CH:15]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8].[CH3:18][N:19]=[C:20]=[O:21].[CH2:22]([Cl:24])Cl>>[Cl:24][C:22]1[CH:15]=[C:6]2[C:5](=[CH:4][CH:3]=1)[N:16]([CH3:17])[C:20](=[O:21])[N:19]([CH3:18])[C:7]2([OH:8])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Komponenten

Edukt 3

HCID 6344Dichloromethane

HCID 12228Methyl Isocyanate

HCID 139252-(Methylamino)-5-chlorobenzophenone

Produkt 1

HCID 23471631HCID 23471631, VerbindungAusbeute 47 %

Versuchsvorschrift

A solution of 12.3 g (0.05 mole) of 5-chloro-2-methylaminobenzophenone and 6 ml (0.1 mole) of methyl isocyanate in 50 ml of methylene chloride was refluxed for 3 days, and then cooled. The solid portion of the reaction mixture was collected on a filter and washed with methylene chloride to give 7.05 g (47%) of 6-chloro-3,4-dihydro-4-hydroxy-1,3-dimethyl-4-phenyl-2(1H)-quinazolinone as light yellow crystals; mp 174°-176°; 1H nmr (DMSO-d6) δ 2.67 ppm (s, 3H), 3.38 ppm (s, 3H), 6.8-7.7 ppm (m, 9H).