Pyrrolidine → 2-(Pyrrolidin-1-yl)-1H-benzo[d]imidazole

HRID 1280476

Reaktionsgleichung

Reaktionsgleichung von HRID 1280476
Cl[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[N:3]=1.[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>C(O)C>[N:11]1([C:2]2[NH:6][C:5]3[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=3[N:3]=2)[CH2:15][CH2:14][CH2:13][CH2:12]1

Komponenten

4

Edukt 2

HCID 31268PyrrolidineHCID 785722-Chlorobenzimidazole

Produkt 1

HCID 69918962-(Pyrrolidin-1-yl)-1H-benzo[d]imidazoleAusbeute 39,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
165 °C

Versuchsvorschrift

2-Chloro-1H-benzimidazole (10.0 g, 0.066 mol), pyrrolidine (18.5 g, 0.26 mol), and ethanol (100 mL) were combined. The resulting solution was heated at 160-170° C. for 6 hours and then the solvent was evaporated. The resulting residue was mixed with water. The mixture was made strongly acidic with hydrochloric acid and then made basic with ammonium hydroxide. The resulting solid was isolated by filtration, washed with water and then air dried to provide 11.8 g of crude product as a tan powder. This material was recrystallized from ethyl acetate/methanol to provide 4.9 g of 2-pyrrolidino-1H-benzimidazole. Analysis: Calculated for C11H13N3: %C, 70.56; %H, 7.00; %N, 22.44; Found: %C, 70.13; %H, 7.05; %N, 22.70.

Aufarbeitung

  1. customthe solvent was evaporated
  2. additionThe resulting residue was mixed with water
  3. customThe resulting solid was isolated by filtration
  4. washwashed with water
  5. customair dried
  6. customto provide 11.8 g of crude product as a tan powder
  7. customThis material was recrystallized from ethyl acetate/methanol

Quellen und Nachweise

ORD-Eintrag
ord-4fecc879cfb649d4b4fba7ee4d29e466
Quelldatensatz
uspto-grants-2002_09
Patentnummer
US06451810B1

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