Aluminium lithium hydride → HCID 15936950, Verbindung

HRID 1280740Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1280740
[H-].[H-].[H-].[H-].[Li+].[Al+3].C[O:8][C:9](=O)[CH:10]([F:19])[CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C1COCC1>[F:19][CH:10]([CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:9][OH:8]

Komponenten

4

Edukt 2

HCID 21226445Aluminium lithium hydrideHCID 86584023HCID 86584023, Verbindung

Produkt 1

HCID 15936950HCID 15936950, VerbindungAusbeute 99,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a 0° C. suspension of LiAlH4 (0.4 g, 10.6 mmol) in dry THF (5 ml) was added dropwise a solution of (RS)-2-fluoro-4-phenyl-butyric acid methyl ester (1 g, 5.3 mmol) in dry THF (10 ml). After 1 hour stirring at 0° C., the reaction mixture was quenched successively with H2O (0.4 ml), 5N NaOH (0.4 ml) and again H2O (1.2 ml). The resulting solid was filtered and the filtrate was concentrated to provide (RS)-2-fluoro-4-phenyl-butan-1-ol (0.89 g, 99%) as a colorless oil, MS: m/e=168.1 (M+).

Aufarbeitung

  1. customthe reaction mixture was quenched successively with H2O (0.4 ml), 5N NaOH (0.4 ml) and again H2O (1.2 ml)
  2. filtrationThe resulting solid was filtered
  3. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-9efcf73044344bba87983126c711ab7b
Quelldatensatz
uspto-grants-2002_09
Patentnummer
US06451819B2

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