Chloroacetyl chloride → HCID 21938676, Verbindung

HRID 1280855Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1280855
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([F:9])[C:3]=1[NH:10][C:11]1[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=1.[Cl:18][CH2:19][C:20](Cl)=[O:21]>>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([F:9])[C:3]=1[N:10]([C:20](=[O:21])[CH2:19][Cl:18])[C:11]1[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=1

Komponenten

3

Edukt 2

HCID 6577Chloroacetyl chlorideHCID 21938673HCID 21938673, Verbindung

Produkt 1

HCID 21938676HCID 21938676, Verbindung

Versuchsvorschrift

A mixture of 230 g (0.9 mol) N-(2′-chloro-4′,6′-difluorophenyl)-4-methylaniline and 325 ml (4.06 mol) of chloroacetyl chloride is heated under a nitrogen atmosphere for one hour at 50°. The solvent is evaporated under reduced pressure to give an oil to which 200 ml of chlorobenzene is added. The solvent is evaporated under reduced pressure to completely remove the chloroacetyl chloride, giving N-(2′-chloro-4′,6′-difluorophenyl)-N-chloroacetyl-4-methylaniline as an oil.

Aufarbeitung

  1. temperatureis heated under a nitrogen atmosphere for one hour at 50°
  2. customThe solvent is evaporated under reduced pressure
  3. customto give an oil to which 200 ml of chlorobenzene
  4. additionis added
  5. customThe solvent is evaporated under reduced pressure
  6. customto completely remove the chloroacetyl chloride

Quellen und Nachweise

ORD-Eintrag
ord-0188f37516a5491e8d59a17fd601ee42
Quelldatensatz
uspto-grants-2002_09
Patentnummer
US06451858B2

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