Potassium Carbonate → 3-Cyclopentyloxy-4-methoxybenzaldehyde

HRID 1281179

Reaktionsgleichung

Reaktionsgleichung von HRID 1281179
[CH:1]1(Cl)[CH2:5][CH2:4][CH2:3][CH2:2]1.[O:7]=[CH:8][C:9]1[CH:17]=[CH:16][C:13]([O:14][CH3:15])=[C:11]([OH:12])[CH:10]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH:1]1([O:12][C:11]2[CH:10]=[C:9]([CH:17]=[CH:16][C:13]=2[O:14][CH3:15])[CH:8]=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 12127Isovanillin2×HCID 70252Chlorocyclopentane

Produkt 1

HCID 27358933-Cyclopentyloxy-4-methoxybenzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
122.5 °C

Versuchsvorschrift

A mixture of cyclopentyl chloride (8.48 g, 0.08 moles), isovanillin (6.12 g, 0.04 moles) and potassium carbonate (1.1 g, 0.08 moles) in dimethylformamide (4.04 g) was stirred in the reactor (100 mL) at 120 to 125° C. for 1.5 hours. A sample was taken to verify the batch conversion. Result (GC): 0.5 area % isovanillin (target:≦1.0 area %). The mixture was cooled to 20° C. and filtered to remove the solid (potassium bicarbonate, potassium chloride). The wet cake was washed with methanol.

Aufarbeitung

  1. customResult (GC)
  2. temperatureThe mixture was cooled to 20° C.
  3. filtrationfiltered
  4. customto remove the solid (potassium bicarbonate, potassium chloride)
  5. washThe wet cake was washed with methanol

Quellen und Nachweise

ORD-Eintrag
ord-18e169bec6dc48c3b09d02436c189918
Quelldatensatz
uspto-grants-2002_09
Patentnummer
US06452022B1

Verknüpfte Notizen

Wird geladen…