Hydrochloric Acid → 5-(3-pyridazinyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione dihydrochloride

HRID 12812Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 12812
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[C:8](=[O:33])[NH:9][C:10](=[O:32])[N:11]([CH2:13][CH2:14][CH2:15][N:16]3[CH2:21][C@H:20]4[C@:18]([C:22]5[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=5)([CH2:19]4)[CH2:17]3)[CH:12]=2)[N:2]=1.[ClH:34].O1CCOCC1>CO>[ClH:34].[ClH:34].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[C:8](=[O:33])[NH:9][C:10](=[O:32])[N:11]([CH2:13][CH2:14][CH2:15][N:16]3[CH2:21][C@H:20]4[C@:18]([C:22]5[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:29])[F:30])=[CH:24][CH:23]=5)([CH2:19]4)[CH2:17]3)[CH:12]=2)[N:2]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 247593395-(3-pyridazinyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione

Produkt 1

HCID 686946285-(3-pyridazinyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

5-(3-pyridazinyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione was dissolved in MeOH and treated with 4N HCl in dioxane solution (2 eq). The solvent was evaporated and the residue triturated with diethyl ether to afford 31 mg of the title compound.

Aufarbeitung

  1. customThe solvent was evaporated
  2. customthe residue triturated with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-dab09068b4ba4c12b3f34435fac22fee
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07727988B2

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