HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Anisole → 8,9-difluoro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Anisole | HCID 7519 | — |
| Edukt | 1-Methylpiperazine | HCID 53167 | — |
| Edukt | Ethyl 2-(2-amino-4,5-difluoroanilino)benzo[b]thiophene-3-carboxylate | HCID 18422150 | — |
| Katalysator | Titanium Tetrachloride | HCID 24193 | — |
| Produkt | 8,9-difluoro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine | HCID 135816405 | — |
Reaktionsschritte
In the same manner as in Example 1 and using ethyl 2-(2-amino-4,5-difluoroanilino)benzo[b]thiophene-3-carboxylate, 1-methylpiperazine, anisole and titanium tetrachloride, 8,9-difluoro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine is obtained.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06455521B1 |
| Quelldatensatz | uspto-grants-2002_09 |
| ORD ID | ord-d53b12cb02f146048619f630e18c4ca8 |
| Quellennotiz | uspto-grants-2002_09 |