Hydrochloric Acid → HCID 18423035, Verbindung

Reaktionsgleichung

C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=2[OH:17])[CH2:6][CH2:5]1)(=O)C.[ClH:18]>>[ClH:18].[ClH:18].[F:16][C:13]1[CH:14]=[CH:15][C:10]([N:7]2[CH2:6][CH2:5][NH:4][CH2:9][CH2:8]2)=[C:11]([OH:17])[CH:12]=1

Komponenten

Edukt 2

HCID 313Hydrochloric Acid

HCID 18423178HCID 18423178, Verbindung

Produkt 1

HCID 18423035HCID 18423035, Verbindung

Versuchsvorschrift

1-Acetyl-4-(4-fluoro-2-hydroxyphenyl)piperazine (0.64 g) was dissolved in a 1.2N aqueous hydrochloric acid solution (16 ml) and refluxed under heating for 7 days. The reaction mixture was concentrated under reduced pressure to give a pale-brown solid. This solid was recrystallized from methanol-ethyl acetate to give the title compound (0.65 g) as pale-brown crystals.

Aufarbeitung

temperaturerefluxed
temperatureunder heating for 7 days
concentrationThe reaction mixture was concentrated under reduced pressure
customto give a pale-brown solid
customThis solid was recrystallized from methanol-ethyl acetate

Quellen und Nachweise

ORD-Eintrag: ord-d479a76381d34c0ca6f1e308faf86f4c
Quelldatensatz: uspto-grants-2002_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06455528B1

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