[CH:1]([OH:3])=O.C(OC(=O)C)(=O)C.[F:11][C:12]([F:26])([F:25])[C:13]1[CH:14]=[C:15]([CH:19]2[CH2:24][CH2:23][CH2:22][NH:21][CH2:20]2)[CH:16]=[CH:17][CH:18]=1.C(=O)(O)[O-].[Na+]>C1C=CC=CC=1>[F:26][C:12]([F:11])([F:25])[C:13]1[CH:14]=[C:15]([CH:19]2[CH2:24][CH2:23][CH2:22][N:21]([CH:1]=[O:3])[CH2:20]2)[CH:16]=[CH:17][CH:18]=13.8 g of mixed formic acid-acetic acid anhydride were added to a solution of 9.8 g of 3-(m-trifluoromethylphenyl)-piperidine in 100 ml of anhydrous benzene and the mixture was stirred for 15 minutes at room temperature and was then poured into 100 ml of aqueous sodium bicarbonate. The mixture was extracted with ethyl acetate and the organic extracts were washed with aqueous sodium chloride, dried over magnesium sulfate and evaporated to dryness to obtain 10 g of 3-(m-trifluoromethylphenyl)-1-piperidine-carboxaldehyde in the form of a colorless resin which was used as is for the next step.
Wird geladen…
