Chloroacetyl chloride → Thiophene-3,4-dicarboxylic acid

HRID 128352

Reaktionsgleichung

Reaktionsgleichung von HRID 128352
ClCC(Cl)=[O:4].[S:6]1[CH:10]=[C:9]2[C:11]([O:13][C:14](=[O:15])[C:8]2=[CH:7]1)=[O:12]>>[S:6]1[CH:10]=[C:9]([C:11]([OH:4])=[O:12])[C:8]([C:14]([OH:13])=[O:15])=[CH:7]1

Komponenten

3

Edukt 2

HCID 6577Chloroacetyl chlorideHCID 3156081H,3H-Thieno[3,4-c]furan-1,3-dione

Produkt 1

HCID 255853Thiophene-3,4-dicarboxylic acid

Versuchsvorschrift

A 25.5 g. portion of 3,4-thiophenedicarboxylic acid {prepared by the method of Kornfeld and Jones [J. Org. Chem., 19, 1671 (1954)]} is suspended in 50 ml. of chloroacetyl chloride and is heated at reflux for 5.5 hours. Excess chloroacetyl chloride is distilled under reduced pressure. The residue is poured into 100 ml. of water and the resulting crystals are collected to yield 16.1 g. of 3,4-thiophenedicarboxylic anhydride.

Aufarbeitung

  1. temperatureat reflux for 5.5 hours
  2. distillationExcess chloroacetyl chloride is distilled under reduced pressure
  3. additionThe residue is poured into 100 ml
  4. customof water and the resulting crystals are collected
  5. customto yield 16.1 g

Quellen und Nachweise

ORD-Eintrag
ord-cdd40e584b9e4651ba74e24770d441ee
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04259476

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