Sulfuric Acid → Propanamide, 2-(dimethylamino)-2-methyl-

HRID 1283546Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1283546
S(=O)(=O)(O)O.[CH3:6][N:7]([CH3:13])[C:8]([CH3:12])([CH3:11])[C:9]#[N:10].[OH-:14].[Ba+2].[OH-]>>[CH3:6][N:7]([CH3:13])[C:8]([CH3:12])([CH3:11])[C:9]([NH2:10])=[O:14]

Komponenten

4

Edukt 3

HCID 1118Sulfuric AcidHCID 6093286Barium hydroxideHCID 105108312-(Dimethylamino)-2-methylpropanenitrile

Produkt 1

HCID 21409863Propanamide, 2-(dimethylamino)-2-methyl-Ausbeute 45 %

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

Conc. Sulphuric acid (8 ml.) was added to 2-dimethylamino-2-methyl-propionitrile (2 g.), and was heated to 90°C and allowed to stand for five mins. The reaction mixture was added to ice cold water (100 ml.), barium hydroxide (32 g.) was added to neutralise the acid and the mixture was filtered (hyflo). The filtrate was evaporated under reduced pressure to give a solid residue which was crystallised from light petroleum (80°-100°C) to give 2-dimethylamino-2-methylpropionamide (1 g. 45%) m.p. 109°-111°C.

Aufarbeitung

  1. additionwas added
  2. filtrationthe mixture was filtered (hyflo)
  3. customThe filtrate was evaporated under reduced pressure
  4. customto give a solid residue which
  5. customwas crystallised from light petroleum (80°-100°C)

Quellen und Nachweise

ORD-Eintrag
ord-0eedefc7dbf448dab6db49e5906563a1
Quelldatensatz
uspto-grants-1976_08
Patentnummer
US03975443

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