p-Anisoyl chloride → 5-Chloro-2-phenyl-3-(4-methoxybenzoyl)benzofuran

HRID 1283657Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1283657
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:7][C:6]=2[CH:16]=1.[C:17](Cl)(=[O:26])[C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[C:7]([C:17](=[O:26])[C:18]3[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=3)[C:6]=2[CH:16]=1

Komponenten

3

Edukt 2

HCID 7477p-Anisoyl chlorideHCID 6150425-Chloro-2-phenylbenzofuran

Produkt 1

HCID 214353985-Chloro-2-phenyl-3-(4-methoxybenzoyl)benzofuran

Versuchsvorschrift

Acylation of 5-chloro-2-phenylbenzofuran with anisoyl chloride was accomplished as described in the procedure of Example 10 to give 5-chloro-2-phenyl-3-(4'-methoxybenzoyl)benzofuran which was then demethylated and the product treated with epichlorohydrin as described above. Opening of the epoxide ring with isopropylamine as previously described gave the title compound.

Quellen und Nachweise

ORD-Eintrag
ord-061a0899f83f444586caf590609848ce
Quelldatensatz
uspto-grants-1976_08
Patentnummer
US03975537

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