Sodium Cyanide → 2-Amino-5-fluorobenzonitrile

HRID 1283710

Reaktionsgleichung

Reaktionsgleichung von HRID 1283710
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4](I)[CH:3]=1.[C-:10]#[N:11].[Na+]>N1C=CC=CC=1>[C:10]([C:4]1[CH:3]=[C:2]([F:1])[CH:8]=[CH:7][C:5]=1[NH2:6])#[N:11]

Komponenten

4

Edukt 2

HCID 8929Sodium CyanideHCID 27782834-Fluoro-2-iodoaniline

Produkt 1

HCID 27377042-Amino-5-fluorobenzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

Fifteen grams of cuprous cyanide and 14 g. of dry pyridine are heated to a homogeneous melt. After adding 25.0 g. of 4-fluoro-2-iodoaniline, the mixture is heated at about 160°-170° C. for two hours. To the cooled mixture, concentrated sodium cyanide solution is added. The solid material is filtered off and extracted with benzene. The benzene extracts are concentrated and fractionally distilled to give 2-cyano-4-fluoroaniline.

Aufarbeitung

  1. additionAfter adding 25.0 g
  2. filtrationThe solid material is filtered off
  3. extractionextracted with benzene
  4. concentrationThe benzene extracts are concentrated
  5. distillationfractionally distilled

Quellen und Nachweise

ORD-Eintrag
ord-993385d6121a41b18f4d4c4b7409be99
Quelldatensatz
uspto-grants-1976_08
Patentnummer
USRE028939

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