HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Bis(Chloromethyl) Ether → 1-(Chloromethyl)-2-fluoro-3,4-dimethoxybenzene
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Bis(Chloromethyl) Ether | HCID 10967 | — |
| Edukt | 2-Fluoro-3,4-dimethoxybenzaldehyde | HCID 603588 | — |
| Edukt | 1-Fluoro-2,3-dimethoxybenzene | HCID 2758979 | — |
| Lösungsmittel | Acetic Acid | HCID 176 | — |
| Produkt | 1-(Chloromethyl)-2-fluoro-3,4-dimethoxybenzene | HCID 237411 | — |
Reaktionsschritte
The 2-fluoroveratraldehyde used as indicated above is prepared as follows: 3-fluoroveratrole is reacted with monochloromethyl ether in glacial acetic acid to give 2-fluoro-3,4-dimethoxybenzyl chloride which is treated with hexamethylenetetramine in chloroform followed by refluxing in 50% acetic acid to yield the 2-fluoroveratraldehyde.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US03976695 |
| Quelldatensatz | uspto-grants-1976_08 |
| ORD ID | ord-698568d1285144f38373b489a08d7a01 |
| Quellennotiz | uspto-grants-1976_08 |