Ammonia → 5-(1-Methylethyl)-8-phenyl-1,3-dioxolo(4,5-g)quinazolin-6(5H)-one

HRID 1284158Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1284158
FC(F)(F)[C:3]([N:5]([CH:23]([CH3:25])[CH3:24])[C:6]1[CH:19]=[C:18]2[O:20][CH2:21][O:22][C:17]2=[CH:16][C:7]=1[C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=O)=[O:4].[NH3:28]>O1CCCC1>[CH:23]([N:5]1[C:6]2[C:7](=[CH:16][C:17]3[O:22][CH2:21][O:20][C:18]=3[CH:19]=2)[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:28][C:3]1=[O:4])([CH3:25])[CH3:24]

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 215156622-(N-trifluoroacetylisopropylamino)-4,5-methylenedioxybenzophenone

Produkt 1

HCID 363315-(1-Methylethyl)-8-phenyl-1,3-dioxolo(4,5-g)quinazolin-6(5H)-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 1.0 g. of 2-(N-trifluoroacetylisopropylamino)-4,5-methylenedioxybenzophenone (prepared as in Example C) and 50 ml. of tetrahydrofuran saturated with anhydrous ammonia is stirred at room temperature for 48 hours. The solvent is removed in vacuo and the residue recrystallized from isopropanol to give 1-isopropyl-4-phenyl-6,7-methylenedioxy-2(1H)-quinazolinone, m.p. 189°-190°C.

Aufarbeitung

  1. additionA mixture of 1.0 g
  2. customThe solvent is removed in vacuo
  3. customthe residue recrystallized from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-7cb795cd1ff446ef8ade630ed8e14f83
Quelldatensatz
uspto-grants-1976_08
Patentnummer
US03978086

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