Reaktionsgleichung
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[O:4]N=1.NC1ON=C(C(C)(C)C)C=1>C(#N)C>[C:5]([CH2:6][C:2]#[N:1])(=[O:4])[C:7]([CH3:10])([CH3:9])[CH3:8]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
This invention relates to a method for optimizing the yield of 3-amino-5-(t-butyl)isoxazole over the yield of the isomeric 5-amino-3-(t-butyl)isoxazole. The method is carried out in a stepwise manner utilizing in a first step the reaction of a lower alkyl pivalate with acetonitrile in the presence of a base to yield pivalyl acetonitrile, which pivalyl acetonitrile is then reacted with hydroxylamine under carefully controlled conditions of pH to yield a preponderance of 3-amino-5-(t-butyl)isoxazole.
Quellen und Nachweise
- ORD-Eintrag
- ord-7a554b4c3abf445080b166ad1234b944
- Quelldatensatz
- uspto-grants-1981_03
- Patentnummer
- US04259501
Verknüpfte Notizen
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