Water → HCID 23469776, Verbindung

HRID 128469

Reaktionsgleichung

Reaktionsgleichung von HRID 128469
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=1)=[O:7].[OH-:15].[Na+].C(Cl)(Cl)Cl.[OH2:21]>CC(C)=O>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([C:8]1[CH:13]=[CH:12][C:11]([O:14][C:8]([CH3:13])([CH3:9])[C:6]([OH:21])=[O:15])=[CH:10][CH:9]=1)=[O:7]

Komponenten

6

Edukt 4

HCID 962WaterHCID 6212ChloroformHCID 14798Sodium HydroxideHCID 20808Ketone, 2-furyl p-hydroxyphenyl

Produkt 1

HCID 23469776HCID 23469776, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

2-Furyl(4-hydroxy-phenyl)ketone (10 g) is dissolved in anhydrous acetone (80 g) and sodium hydroxide (13.2 g) is added thereto; the resulting mixture is stirred for 30 minutes after which anhydrous chloroform (20 g) is added dropwise thereto. On completion of the addition, the mixture is refluxed for 10 hrs. After cooling, the suspension is poured over 2 volumes water and the acetone is evaporated under reduced pressure. The aqueous phase is made acidic, and is then extracted with ethyl ether. The ether phase is neutralized, dried, and the solvent is evaporated off. The resulting solid is recrystallized from benzene, to give 9 g of acid which melts at 127° C. (B)

Aufarbeitung

  1. additionis added dropwise
  2. additionOn completion of the addition
  3. temperaturethe mixture is refluxed for 10 hrs
  4. temperatureAfter cooling
  5. customthe acetone is evaporated under reduced pressure
  6. extractionis then extracted with ethyl ether
  7. customdried
  8. customthe solvent is evaporated off
  9. customThe resulting solid is recrystallized from benzene

Quellen und Nachweise

ORD-Eintrag
ord-1e31f9fe3cb7497489d1fc43d7b7487d
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04259509

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