Thionyl Chloride → 2-[[4-[4-(Trifluoromethoxy)phenoxy]phenoxy]]propanoyl chloride

HRID 128495

Reaktionsgleichung

Reaktionsgleichung von HRID 128495
[F:1][C:2]([F:24])([F:23])[O:3][C:4]1[CH:22]=[CH:21][C:7]([O:8][C:9]2[CH:20]=[CH:19][C:12]([O:13][CH:14]([CH3:18])[C:15](O)=[O:16])=[CH:11][CH:10]=2)=[CH:6][CH:5]=1.S(Cl)([Cl:27])=O>CN(C=O)C>[F:1][C:2]([F:24])([F:23])[O:3][C:4]1[CH:22]=[CH:21][C:7]([O:8][C:9]2[CH:20]=[CH:19][C:12]([O:13][CH:14]([CH3:18])[C:15]([Cl:27])=[O:16])=[CH:11][CH:10]=2)=[CH:6][CH:5]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 23469824HCID 23469824, Verbindung

Produkt 1

HCID 234698232-[[4-[4-(Trifluoromethoxy)phenoxy]phenoxy]]propanoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To 17.11 g. (0.05 mole) of 2-[[4-[4-(trifluoromethoxy)phenoxy]phenoxy]]propanoic acid is added 1 ml. of DMF, followed by 50 ml. of thionyl chloride. After evolution of HCl ceases, the thionyl chloride excess is removed in vacuum. The residue is extracted with methylene chloride and the methylene chloride solution washed with ice water, dried, and the solvent removed, leaving 2-[[4-[4-(trifluoromethoxy)phenoxy]-phenoxy]]propanoyl chloride.

Aufarbeitung

  1. customAfter evolution of HCl ceases, the thionyl chloride excess is removed in vacuum
  2. extractionThe residue is extracted with methylene chloride
  3. washthe methylene chloride solution washed with ice water
  4. customdried
  5. customthe solvent removed

Quellen und Nachweise

ORD-Eintrag
ord-f45e87b23fb34b9daf983d84e798b337
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04259532

Verknüpfte Notizen

Wird geladen…