p-Toluenesulfonic acid monohydrate → 5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one p-toluenesulfonate

HRID 1285127Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1285127
[CH3:1][C:2]1[NH:3][C:4](=[O:14])[CH2:5][S:6][C:7]=1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1.O.[C:16]1([CH3:26])[CH:21]=[CH:20][C:19]([S:22]([OH:25])(=[O:24])=[O:23])=[CH:18][CH:17]=1>CO>[C:16]1([CH3:26])[CH:17]=[CH:18][C:19]([S:22]([OH:25])(=[O:23])=[O:24])=[CH:20][CH:21]=1.[CH3:1][C:2]1[NH:3][C:4](=[O:14])[CH2:5][S:6][C:7]=1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1

Komponenten

4

Edukt 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 30625322H-1,4-Thiazin-3(4H)-one, 5-methyl-6-(4-pyridinyl)-

Produkt 1

HCID 202498855-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one p-toluenesulfonateAusbeute 62,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one (0.88 g) in methanol (30 ml), p-toluenesulfonic acid monohydrate (0.97 g) was gradually added. The reaction mixture was stirred at room temperature for 30 minutes. Methanol was removed under reduced pressure and the residue was recrystallized from ethanol to give 5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one p-toluenesulfonate (1 g, yield 62.5%) as yellow fine needles.

Aufarbeitung

  1. customMethanol was removed under reduced pressure
  2. customthe residue was recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-ac70f367dd39476eb09431d1f6e3527f
Quelldatensatz
uspto-grants-1986_01
Patentnummer
US04565813

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