Hydrochloric Acid → HCID 10037407, Verbindung

HRID 1285128Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1285128
[CH3:1][C:2]1[NH:3][C:4](=[O:14])[CH2:5][S:6][C:7]=1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1.[ClH:15]>CO>[ClH:15].[CH3:1][C:2]1[NH:3][C:4](=[O:14])[CH2:5][S:6][C:7]=1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 30625322H-1,4-Thiazin-3(4H)-one, 5-methyl-6-(4-pyridinyl)-

Produkt 1

HCID 10037407HCID 10037407, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one (5 g) in methanol (500 ml), 12N hydrochloric acid (4 ml) was added dropwise with stirring at room temperature. The reaction mixture was stirred at room temperature for 1 hour and then concentrated in vacuo. Tetrahydrofuran (200 ml) was added and the reaction mixture was stirred at room temperature for 10 minutes, and then filtered. The residue was recrystallized from ethanol to give 4.6 g of 5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one hydrochloride as pale yellow needles.

Aufarbeitung

  1. stirringThe reaction mixture was stirred at room temperature for 1 hour
  2. concentrationconcentrated in vacuo
  3. additionTetrahydrofuran (200 ml) was added
  4. stirringthe reaction mixture was stirred at room temperature for 10 minutes
  5. filtrationfiltered
  6. customThe residue was recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-c42afcba0ee649bfa06367f523f8df78
Quelldatensatz
uspto-grants-1986_01
Patentnummer
US04565813

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