Diethylamine → 7-[(5-Diethylaminomethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline-hydrochloride salt

HRID 1285164Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1285164
[Cl:1][CH2:2][C:3]1[O:7][N:6]=[C:5]([CH2:8][N:9]2[C:18]3[C:17](=[O:19])[N:15]([CH3:16])[C:14](=[O:20])[N:13]([CH3:21])[C:12]=3[N:11]=[CH:10]2)[N:4]=1.[CH2:22]([NH:24][CH2:25][CH3:26])[CH3:23]>C1(C)C=CC=CC=1>[ClH:1].[CH2:22]([N:24]([CH2:2][C:3]1[O:7][N:6]=[C:5]([CH2:8][N:9]2[C:18]3[C:17](=[O:19])[N:15]([CH3:16])[C:14](=[O:20])[N:13]([CH3:21])[C:12]=3[N:11]=[CH:10]2)[N:4]=1)[CH2:25][CH3:26])[CH3:23]

Komponenten

4

Edukt 2

HCID 8021DiethylamineHCID 202498997-[(5-Chloromethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline

Produkt 1

HCID 202499047-[(5-Diethylaminomethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline-hydrochloride salt

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

9.0 g. of 7-[(5-chloromethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline, 6 cm3 diethylamine and 50 cm3 toluene are heated on water bath for 8 hours under stirring. The mixture is evaporated at reduced pressure and the residue is washed with water, dissolved in 50 cm3 hot ethanol, treated with activated charcoal and treated with ethanol in hydrochloric acid. 8.3 g of 7-[(5-diethylaminomethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline-hydrochloride salt are obtained. M.p.: 207°-210° C.

Aufarbeitung

  1. customThe mixture is evaporated at reduced pressure
  2. washthe residue is washed with water
  3. dissolutiondissolved in 50 cm3 hot ethanol
  4. additiontreated with activated charcoal
  5. additiontreated with ethanol in hydrochloric acid

Quellen und Nachweise

ORD-Eintrag
ord-78a7ee4f793449e9bdd6877a0a10ff67
Quelldatensatz
uspto-grants-1986_01
Patentnummer
US04565817

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