Thiourea → HCID 178456240, Verbindung

HRID 1285203Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1285203
[CH2:1]([N:4]1[C@H:13]2[C@@H:8]([CH2:9][C:10](=O)[C:11](=[CH:14]N(C)C)[CH2:12]2)[CH2:7][CH2:6][CH2:5]1)[CH2:2][CH3:3].[NH2:19][C:20]([NH2:22])=[S:21]>C(O)C>[SH:21][C:20]1[N:22]=[CH:14][C:11]2[CH2:12][C@H:13]3[C@@H:8]([CH2:7][CH2:6][CH2:5][N:4]3[CH2:1][CH2:2][CH3:3])[CH2:9][C:10]=2[N:19]=1

Komponenten

4

Edukt 2

HCID 2723790ThioureaHCID 54074822trans-(+/-)-1-n-Propyl-6-oxo-7-dimethylaminomethylenedecahydroquinoline

Produkt 1

HCID 178456240HCID 178456240, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

One gram of trans-(±)-1-n-propyl-6-oxo-7-dimethylaminomethylenedecahydroquinoline was reacted with 0.33 g. of thiourea in 20 ml. of ethanol by refluxing overnight under a nitrogen atmosphere. The volatile constituents were removed in vacuo to yield trans-(±)-2-mercapto-6-n-propyl-5,5a,6,7,8,9,9a,10-octahydropyrimido[4,5-g]quinoline free base. The free base was converted to the dihydrochloride salt by standard procedures to yield 0.17 g. of dihydrochloride salt melting at 267°-277° C. after recrystallization from methanol.

Aufarbeitung

  1. customThe volatile constituents were removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-b442f10766e144758b98da0cfc36f55d
Quelldatensatz
uspto-grants-1986_01
Patentnummer
US04565871

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