(+-)-3,4-Dimethoxyamphetamine → Ammonia

HRID 1285584

Reaktionsgleichung

Reaktionsgleichung von HRID 1285584
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH:12]([NH2:14])[CH3:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[CH2:15]1[O:17][CH:16]1[CH2:18][OH:19]>C(O)(C)C>[NH3:14].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH:12]([NH:14][CH2:15][CH:16]([OH:17])[CH2:18][OH:19])[CH3:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Komponenten

5

Edukt 2

HCID 8423(+-)-3,4-DimethoxyamphetamineHCID 11164Glycidol

Produkt 2

HCID 222AmmoniaHCID 537726823-[3-(3,4-Dimethoxyphenyl)-2-propylamino]1,2-propanediol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel2×

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

A solution of 3-(3,4-dimethoxyphenyl)-2-propylamine (20.0 g., 0.10 m.) in isopropanol (20 ml.) is heated to 50° C. while a solution of glycidol (5.0 g., 0.067 m.) in isopropanol (5 ml.) is added over 15 minutes. The mixture is stirred at 50° C. for 0.5 hours and then at 70° C. for 16 hours. The solvent is concentrated under reduced pressure and the residue is chromatographed on silica gel, eluting with 10% MeOH--CHCl3 saturated with NH3 to yield (I) weighing 14.37 g. (80%).

Aufarbeitung

  1. additionis added over 15 minutes
  2. waitat 70° C. for 16 hours
  3. concentrationThe solvent is concentrated under reduced pressure
  4. customthe residue is chromatographed on silica gel
  5. washeluting with 10% MeOH

Quellen und Nachweise

ORD-Eintrag
ord-74792e90ea7c4b5b859c225590ac411b
Quelldatensatz
uspto-grants-1986_01
Patentnummer
US04567276

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