Hydrochloric Acid → 2-Methoxy-4-(4-piperidyloxy)benzoic acid

HRID 128583Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 128583
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH:13]2[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].Cl>C(OCC)(=O)C>[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 105458744-((1-(Tert-butoxycarbonyl)piperidin-4-YL)oxy)-2-methoxybenzoic acid

Produkt 1

HCID 189141672-Methoxy-4-(4-piperidyloxy)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

2-Methoxy-4-(1-Boc-4-piperidyloxy)benzoic acid (0.79 g, 2.24 mmol) was dissolved in ethyl acetate (15 ml). The solution was cooled in ice and saturated with HCl gas, then stirred 30 min in the cold. The mixture was evaporated in vacuo and the residue concentrated from ether three times to give 2-methoxy-4-(4-piperidyloxy)benzoic acid.

Aufarbeitung

  1. customThe mixture was evaporated in vacuo
  2. concentrationthe residue concentrated from ether three times

Quellen und Nachweise

ORD-Eintrag
ord-6b356e6778eb45fba5460e10af218b03
Quelldatensatz
uspto-grants-1995_11
Patentnummer
US05464788

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