2-(Methylamino)ethanol → N-(beta-hydroxyethyl)-N-methyl-N'-(2-t-butyl-1,3,4-thiadiazol-5-yl)urea

HRID 1287176Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1287176
[C:1]([C:5]1[S:6][C:7]([N:10]=[C:11]=[O:12])=[N:8][N:9]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:13][NH:14][CH2:15][CH2:16][OH:17]>C(OCC)(=O)C>[OH:17][CH2:16][CH2:15][N:14]([CH3:13])[C:11]([NH:10][C:7]1[S:6][C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])=[N:9][N:8]=1)=[O:12]

Komponenten

4

Edukt 2

HCID 80162-(Methylamino)ethanolHCID 64524562-t-Butyl-1,3,4-thiadiazol-5-yl Isocyanate

Produkt 1

HCID 21507110N-(beta-hydroxyethyl)-N-methyl-N'-(2-t-butyl-1,3,4-thiadiazol-5-yl)urea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

2-t-Butyl-1,3,4-thiadiazol-5-yl isocyanate dimer (10 grams), N-methyl-N-β-hydroxyethylamine (4.4 grams) and ethyl acetate (50 ml) were charged into a glass reaction vessel equipped with a mechanical stirrer, reflux condenser and thermometer. The reaction mixture was heated at reflux with stirring for a period of about 2 hours. After this time the reaction mixture was stripped of solvent under reduced pressure to yield the desired product N-(β-hydroxyethyl)-N-methyl-N'-(2-t-butyl-1,3,4-thiadiazol-5-yl)urea as an oily residue.

Aufarbeitung

  1. customequipped with a mechanical stirrer
  2. temperaturereflux condenser
  3. temperatureThe reaction mixture was heated
  4. temperatureat reflux

Quellen und Nachweise

ORD-Eintrag
ord-a522f4f5125b4f38a55a456224681f06
Quelldatensatz
uspto-grants-1976_10
Patentnummer
US03984228

Notizen zur Reaktion

Wird geladen…