Acetone → HCID 178444015, Verbindung

HRID 1287408

Reaktionsgleichung

Reaktionsgleichung von HRID 1287408
[Na].CC(C)=O.Cl.[C:7]([NH2:15])(=[NH:14])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].[Cl:16][C:17]1[CH:22]=[C:21]([CH3:23])[CH:20]=[CH:19][C:18]=1[N:24]=[C:25]=[S:26]>C1C=CC=CC=1.CCCCC>[Cl:16][C:17]1[CH:22]=[C:21]([CH3:23])[CH:20]=[CH:19][C:18]=1[NH:24][C:25]([NH:14][C:7](=[NH:15])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])=[S:26]

Komponenten

6

Edukt 4

HCID 180Acetone2×HCID 1435292-Chloro-4-methylphenyl isothiocyanateHCID 5360545SodiumHCID 14144282Heptanimidamide hydrochloride

Produkt 1

HCID 178444015HCID 178444015, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 19707280Benzene n-pentaneLösungsmittel

Versuchsvorschrift

Following a procedure similar to that described in Example 42 and using 2.3 g. sodium in 250 ml. dry acetone, 16.4 g. heptanamidine hydrochloride, and 16 g. 2-chloro-4-methylphenyl isothiocyanate (b.p. 80°-82°C./0.3 mm.; prepared from 2-chloro-4-methylaniline) in 100 ml. dry acetone there was obtained 1-(2-chloro-4-methylphenyl)-3-(heptanimidoyl)-2-thiourea, m.p. 78°-80°C. (from benzene-n-pentane); hydrochloride (23 g.), m.p. 138°-140°C. (from isopropyl alcohol).

Quellen und Nachweise

ORD-Eintrag
ord-b0270527fc824ddfa2752b037e6a82c8
Quelldatensatz
uspto-grants-1976_10
Patentnummer
US03984467

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