Ethyl formate → N-[2-(Benzyloxy)-5-(pyridine-2-carbonyl)phenyl]formamide

HRID 1287845Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1287845
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:11]([NH2:23])[CH:10]=1)=[O:8].[CH:24](OCC)=[O:25]>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[C:11]([NH:23][CH:24]=[O:25])[CH:10]=1)=[O:8]

Komponenten

3

Edukt 2

HCID 8025Ethyl formateHCID 538809743-Amino-4-benzyloxyphenyl 2-pyridyl ketone

Produkt 1

HCID 53784995N-[2-(Benzyloxy)-5-(pyridine-2-carbonyl)phenyl]formamide

Versuchsvorschrift

A mixture of 10.0 g (32.8 mmol) of 3-amino-4-benzyloxyphenyl 2-pyridyl ketone and 200 ml of ethyl formate is refluxed with stirring for 24 hours. The reaction mixture is evaporated and the residue is dissolved in methylene chloride, then is washed with dilute HCl and saturated saline solution. The dried organic phase is evaporated to give 4-benzyloxy-3-formamidophenyl 2-pyridyl ketone.

Aufarbeitung

  1. temperatureis refluxed
  2. customThe reaction mixture is evaporated
  3. dissolutionthe residue is dissolved in methylene chloride
  4. washis washed with dilute HCl and saturated saline solution
  5. customThe dried organic phase is evaporated

Quellen und Nachweise

ORD-Eintrag
ord-1f66b970818545b9a5dd8f3b7f9dc50e
Quelldatensatz
uspto-grants-1976_10
Patentnummer
US03985887

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