Hydrochloric Acid → 6-Chloro1,3-dihydro-1'-methylspiro[isobenzofuran-1,4'-piperidine]

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Reaktionsgleichung

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]O)=[C:4]([C:10]2([OH:17])[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]2)[CH:3]=1.Cl>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:5]([CH2:8][O:17][C:10]32[CH2:11][CH2:12][N:13]([CH3:16])[CH2:14][CH2:15]3)=[CH:6][CH:7]=1

Komponenten

Edukt 2

HCID 313Hydrochloric Acid

HCID 867335284-(4-Chloro-alpha-hydroxy-2-tolyl)-4-hydroxy-1-methylpiperidine

Produkt 1

HCID 215068256-Chloro1,3-dihydro-1'-methylspiro[isobenzofuran-1,4'-piperidine]

Versuchsvorschrift

Treatment of 4-(4-chloro-α-hydroxy-2-tolyl)-4-hydroxy-1-methylpiperidine with hydrochloric acid by the method described in Example 16d provides 6-chloro1,3-dihydro-1'-methylspiro[isobenzofuran-1,4'-piperidine].

Quellen und Nachweise

ORD-Eintrag: ord-68da0d01f6414d29b21b18a62f368c2f
Quelldatensatz: uspto-grants-1976_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US03985889

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