Hydrochloric Acid → 11-Chloro-1,2,4,5-tetrahydro-3H-azepino[4,5-b]quinoline dihydrochloride
Reaktionsgleichung
[Cl:1][C:2]1[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:5]=[C:4]2[CH2:12][CH2:13][N:14](C(OCC)=O)[CH2:15][CH2:16][C:3]=12.[ClH:22].C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl>>[ClH:1].[ClH:22].[Cl:1][C:2]1[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:5]=[C:4]2[CH2:12][CH2:13][NH:14][CH2:15][CH2:16][C:3]=12Komponenten
4
Versuchsvorschrift
11-Chloro-1,2,4,5-tetrahydro-3H-azepino[4,5-b]quinoline dihydrochloride was prepared by hydrolysis of 11-chloro-3-phenoxycarboxyl-1,2,4,5-tetrahydro-3H-azepino[4,5-b]quinoline or 11-chloro-3-ethoxycarbonyl-1,2,4,5-tetrahydro-3H-azepino[4,5-b]quinoline with concentrated hydrochloric acid. Yield of the dihydrochloride: 69% of theory; m.p. 261° C. (decomp.).