HCID 21950481, Verbindung → 2-(Methanesulfonyl)benzonitrile

HRID 1288266Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1288266
[CH3:1][S:2]([C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7]([NH2:9])=O)(=[O:4])=[O:3]>P(Cl)(Cl)(Cl)=O>[CH3:1][S:2]([C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7]#[N:9])(=[O:3])=[O:4]

Komponenten

3

Edukt 1

HCID 21950481HCID 21950481, Verbindung

Produkt 1

HCID 223462902-(Methanesulfonyl)benzonitrileAusbeute 87,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 24813Phosphorus oxychlorideLösungsmittel

Versuchsvorschrift

2-Methanesulphonylbenzamide (34 g.) was added to phosphorus oxychloride (100 ml.) and the mixture was refluxed for 90 minutes. The excess of phosphorus oxychloride was evaporated in vacuo, and the oily residue was treated with water (200 ml.), with ice cooling. The solid which separated was filtered off, washed with water and recrystallised from ethanol to give 2-methanesulphonylbenzonitrile (27 g.), m.p. 105°-106° C.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 90 minutes
  2. customThe excess of phosphorus oxychloride was evaporated in vacuo
  3. additionthe oily residue was treated with water (200 ml.), with ice cooling
  4. customThe solid which separated
  5. filtrationwas filtered off
  6. washwashed with water
  7. customrecrystallised from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-394b98742ce743418c8da40afff7a674
Quelldatensatz
uspto-grants-1976_10
Patentnummer
US03987160

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