2-Aminophenol → 2-p-Tolylbenzoxazole

Reaktionsgleichung

[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.NC1C=CC=CC=1O.[CH3:18][C:19]1[CH:20]=[CH:21][C:22](C(O)=O)=[CH:23][CH:24]=1>>[C:19]1([CH3:18])[CH:20]=[CH:21][C:22]([C:2]2[O:1][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[N:3]=2)=[CH:23][CH:24]=1

Komponenten

Edukt 3

HCID 58012-Aminophenol

HCID 7470P-Toluic Acid

HCID 9228Benzoxazole

Produkt 1

HCID 700392-p-Tolylbenzoxazole

Versuchsvorschrift

Preparation of the above benzoxazole reactant is as follows: o-aminophenol is reacted with p-toluic acid to yield 2-(p-tolyl)benzoxazole; this intermediate is then brominated with N-bromosuccinimide to obtain 2-4-bromomethylphenyl)-benzoxazole.

Quellen und Nachweise

ORD-Eintrag: ord-f8d332b913374a5a9a11e20767997fbe
Quelldatensatz: uspto-grants-1976_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US03988295

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