Sodium Carbonate → 1-[(6-Methylnaphthalen-2-yl)methyl]-4-(pyridin-2-yl)piperazine

HRID 1288570Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1288570
Cl[CH2:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:13])[CH:9]=2)[CH:4]=1.C(=O)([O-])[O-].[Na+].[Na+].[N:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>CN(C)C=O>[CH3:13][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[CH:4]=[C:3]([CH2:2][N:29]1[CH2:30][CH2:31][N:26]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][N:20]=3)[CH2:27][CH2:28]1)[CH:12]=[CH:11]2

Komponenten

5

Edukt 3

HCID 10340Sodium CarbonateHCID 944591-(2-Pyridyl)piperazineHCID 133015572-(Chloromethyl)-6-methylnaphthalene

Produkt 1

HCID 215029051-[(6-Methylnaphthalen-2-yl)methyl]-4-(pyridin-2-yl)piperazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 11.0 g. of 2-chloromethyl-6-methylnaphthalene, 7.0 g. of sodium carbonate and 10.0 g. of 2-pyridylpiperazine in 75 ml. of dimethylformamide is stirred for six hours. The reaction mixture is cooled, filtered and the filtrate is concentrated. The precipitate is then washed with water and crystallized from ethanol to yield 1-(6-methyl-β-naphthylmethyl)-4-(2-pyridyl)piperazine.

Aufarbeitung

  1. additionA mixture of 11.0 g
  2. temperatureThe reaction mixture is cooled
  3. filtrationfiltered
  4. concentrationthe filtrate is concentrated
  5. washThe precipitate is then washed with water
  6. customcrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-f2b254025cd644c7b169da9058ff52bd
Quelldatensatz
uspto-grants-1976_10
Patentnummer
US03988457

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