Hydrogen Bromide → 6-{[4-(Pyridin-2-yl)piperazin-1-yl]methyl}naphthalen-1-ol

HRID 1288571Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1288571
C[O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]=[CH:6][C:7]([CH2:13][N:14]1[CH2:19][CH2:18][N:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=3)[CH2:16][CH2:15]1)=[CH:8]2.Br>>[OH:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]=[CH:6][C:7]([CH2:13][N:14]1[CH2:15][CH2:16][N:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=3)[CH2:18][CH2:19]1)=[CH:8]2

Komponenten

3

Edukt 2

HCID 260Hydrogen BromideHCID 215029101-[(5-Methoxynaphthalen-2-yl)methyl]-4-(pyridin-2-yl)piperazine

Produkt 1

HCID 215029076-{[4-(Pyridin-2-yl)piperazin-1-yl]methyl}naphthalen-1-ol

Versuchsvorschrift

A solution of 3.4 g. of 1-(5-methoxy-β-naphthylmethyl)-4-(2-pyridyl)piperazine in 100 ml. of 48% hydrogen bromide is refluxed for 3 hours. The mixture is cooled, concentrated and treated with sodium carbonate. The mixture is extracted with chloroform and the chloroform extractions are dried to yield 1-(5-hydroxy-β-naphtylmethyl)-4-(2-pyridyl)piperazine.

Aufarbeitung

  1. temperatureThe mixture is cooled
  2. concentrationconcentrated
  3. additiontreated with sodium carbonate
  4. extractionThe mixture is extracted with chloroform
  5. extractionthe chloroform extractions
  6. customare dried

Quellen und Nachweise

ORD-Eintrag
ord-06a78da21a1248aa942cd52eed35122b
Quelldatensatz
uspto-grants-1976_10
Patentnummer
US03988457

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