Formaldehyde → Methylglyoxal

HRID 1288662

Reaktionsgleichung

Reaktionsgleichung von HRID 1288662
[NH2:1][C@@H:2]([CH2:6][CH2:7][C:8]([NH:10][C@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH2:12][SH:13])=[O:9])[C:3]([OH:5])=[O:4].C=O.C(C(/C=C\C(O)=O)=O)C(CC(O)=O)=[O:25].ClC(Cl)(Cl)C(C1C=CC(Cl)=CC=1)C1C=CC(Cl)=CC=1>>[CH3:6][C:2]([CH:3]=[O:5])=[O:25].[NH2:1][C@@H:2]([CH2:6][CH2:7][C:8]([NH:10][C@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH2:12][SH:13])=[O:9])[C:3]([OH:5])=[O:4]

Komponenten

6

Edukt 4

HCID 712FormaldehydeHCID 30361-Chloro-4-(2,2,2-trichloro-1-(4-chlorophenyl)ethyl)benzeneHCID 124886GlutathioneHCID 52803934-Maleylacetoacetic acid

Produkt 2

HCID 880MethylglyoxalHCID 124886Glutathione

Versuchsvorschrift

Glutathione functions as a co-enzyme for formaldehyde dehydrogenase, maleylacetoacetate isomerase, glyoxalase, prostaglandin endoperoxidase isomerases, and dichlorodiphenyltrichloroethane dehydrochlorinase and similar enzymes. In the glyoxalase reaction, the hemimercaptal formed nonenzymatically by reaction of methylglyoxal and glutathione (GSH) is converted by glyoxalase I to S-lactyl-Glutathione, which is split by glyoxalase II to D-lactate and Glutathione. In the formaldehyde dehydrogenase reaction, S-formyl Glutathione is formed (Glutathione+HCHO+NAD+) and hydrolyzed to formate and Glutathione.

Aufarbeitung

  1. customIn the glyoxalase reaction

Quellen und Nachweise

ORD-Eintrag
ord-20f240749d8c4433b23b4769c315dad3
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05747329

Verknüpfte Notizen

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