Sodium Acetate → 5-[[4-[(2-Chloro-6-fluorophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone

Beteiligte Stoffe

Reaktionsschritte

Under a nitrogen atmosphere in a round bottom flask 4-[(2-chloro-6-fluorophenyl)methoxy]benzaldehyde (1.00 g, 3.78 mmol) was dissolved in acetic acid (19 ml). To this solution was added sodium acetate (1.08 g, 13.2 mmol) and then rhodanine (0.50 g, 3.75 mmol). The reaction mixture was then heated to reflux and maintained at this temeprature. The progress of the reaction was monitored by thin layer chromatography.

Herkunft & Nachweise