Methyl iodide → 2-Methoxy-4-phenoxybromobenzene

HRID 1289181Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1289181
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:4][C:3]=1[OH:15].[C:16]([O-])([O-])=O.[K+].[K+].IC>CC(C)=O>[CH3:16][O:15][C:3]1[CH:4]=[C:5]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:7][C:2]=1[Br:1]

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 189257712-Bromo-5-phenoxyphenol

Produkt 1

HCID 189257722-Methoxy-4-phenoxybromobenzeneAusbeute 92,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a solution of 2-bromo-5-phenoxyphenol (0.38 g, 1.4 mmol) in 6 ml acetone was added K2CO3 (0.58 g, 4.2 mmol) and iodomethane (0.26 ml, 4.2 mmol). The-reaction mixture was heated to reflux for 8 h, cooled to ambient temperature and filtered. The solvent was removed under reduced pressure and the residue was taken up in EtOAc. The organic phase was washed with 1N NaOH, water and brine. Drying over Na2SO4 afforded 0.36 g (92%) of 2-methoxy-4-phenoxybromobenzene.

Aufarbeitung

  1. customThe-reaction mixture
  2. temperaturewas heated
  3. temperatureto reflux for 8 h
  4. filtrationfiltered
  5. customThe solvent was removed under reduced pressure
  6. washThe organic phase was washed with 1N NaOH, water and brine
  7. dry with materialDrying over Na2SO4

Quellen und Nachweise

ORD-Eintrag
ord-5df851b9137742cdb02a7035877fd118
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05747540

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