Guanidine → HCID 15841104, Verbindung

HRID 1289214Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1289214
[CH3:1][C:2]1[CH:10]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]([C:18]([F:21])([F:20])[F:19])=[CH:7][C:3]=1[C:4](O)=[O:5].CC1C=C(OC2C=CC=CC=2)C(Br)=CC=1C(OC)=O.FC(F)(F)C([O-])=O.[K+].C(N1C=CN=C1)(N1C=CN=C1)=O.[NH2:61][C:62]([NH2:64])=[NH:63]>[I-].C[N+](C)(C)C.C1COCC1>[NH2:63][C:62]([NH2:64])=[N:61][C:4](=[O:5])[C:3]1[CH:7]=[C:8]([C:18]([F:21])([F:20])[F:19])[C:9]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:10][C:2]=1[CH3:1]

Komponenten

8

Edukt 5

HCID 3520GuanidineHCID 682631,1'-CarbonyldiimidazoleHCID 15841102HCID 15841102, VerbindungHCID 15841103HCID 15841103, VerbindungHCID 23662811Potassium trifluoroacetate

Produkt 1

HCID 15841104HCID 15841104, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6381Tetramethylammonium iodideKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 0.5 g of 2-methyl-4-phenoxy5-trifluoromethylbenzoic acid [obtainable by reaction of methyl 2-methyl-4-phenoxy-5-bromobenzoate with potassium trifluoroacetate in the presence of Cul and tetramethylammonium iodide and subsequent hydrolysis] and 300 mg of carbonyldiimidazole in 15 ml of THF is stirred at room temperature for two hours and then added to 383 mg of guanidine. The mixture is stirred for a further two hours. After customary working up, N-diaminomethylene-2-methyl-4-phenoxy-5-trifluoromethylbenzamide is obtained.

Aufarbeitung

  1. stirringThe mixture is stirred for a further two hours

Quellen und Nachweise

ORD-Eintrag
ord-d6bba8111a0248c1b7b81e7ae27eeeac
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05747539

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