Pivaloyl chloride → Nalbuphine pivalate

HRID 1289466Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1289466
[CH:1]1[C:6]2[CH2:7][C@H:8]3[N:13]([CH2:14][CH:15]4[CH2:18][CH2:17][CH2:16]4)[CH2:12][CH2:11][C@:10]45[C@H:19]([C@@H:21]([OH:24])[CH2:22][CH2:23][C@@:9]34[OH:25])[O:20][C:4]([C:5]=25)=[C:3]([OH:26])[CH:2]=1.[C:27](Cl)(=[O:32])[C:28]([CH3:31])([CH3:30])[CH3:29]>C(Cl)Cl>[CH:1]1[C:6]2[CH2:7][C@H:8]3[N:13]([CH2:14][CH:15]4[CH2:18][CH2:17][CH2:16]4)[CH2:12][CH2:11][C@:10]45[C@H:19]([C@@H:21]([OH:24])[CH2:22][CH2:23][C@@:9]34[OH:25])[O:20][C:4]([C:5]=25)=[C:3]([OH:26])[CH:2]=1.[C:27]([O-:32])(=[O:20])[C:28]([CH3:31])([CH3:30])[CH3:29]

Komponenten

4

Edukt 2

HCID 62493Pivaloyl chlorideHCID 5311304Nalbuphine

Produkt 1

HCID 86752539Nalbuphine pivalate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

75 mL of methylene chloride and 3.75 g (0.01 mole) of nalbuphine were placed in a 250-mL ice-bathed round-bottomed flask. While stirring, 0.01 mole of pivaloyl chloride dissolved in 20 mL of methylene chloride was added gradually. Following the procedure as described in Example 1, pure nalbuphine pivalate was obtained. The physical data are shown in Table 1 and FIGS. 6, 7 and 8.

Aufarbeitung

  1. additionwas added gradually

Quellen und Nachweise

ORD-Eintrag
ord-2b1094df3d994fc5a56eaef7e40d4eca
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05750534

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