Methyl isothiocyanate → 5-amino-N-methyl-1,2,4-triazole-1-carbothioamide

HRID 1289773Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1289773
[NH2:1][C:2]1[N:6]=[CH:5][NH:4][N:3]=1.[CH3:7][N:8]=[C:9]=[S:10]>CN(C)C=O>[NH2:1][C:2]1[N:3]([C:9]([NH:8][CH3:7])=[S:10])[N:4]=[CH:5][N:6]=1

Komponenten

4

Edukt 2

HCID 11167Methyl isothiocyanateHCID 178418311HCID 178418311, Verbindung

Produkt 1

HCID 32648395-amino-N-methyl-1,2,4-triazole-1-carbothioamideAusbeute 18,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

The synthesis method of Example 1-(3) was applied. 3-Amino-1H-1,2,4-triazole (3.91 g), dimethylformamide (20 ml) and methyl isothiocyanate (3.41 g) were used as reagents. After the reaction, the resulting substance was removed by filtration and the filtrate was extracted with ethyl acetate, after which the obtained white solid was recrystallized from ethanol and ethyl acetate to give 1.34 g of yellow crystals (yield 18%).

Aufarbeitung

  1. customAfter the reaction
  2. customthe resulting substance was removed by filtration
  3. extractionthe filtrate was extracted with ethyl acetate
  4. customafter which the obtained white solid was recrystallized from ethanol and ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-f3be477bcbdf4878a39f5055172e576b
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05750545

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