Hydrochloric Acid → Ethyl pentanimidate hydrochloride

Temperatur

0 °C

Hydrogen chloride gas was bubbled into a tared solution of valeronitrile (92.0 g, 1.08 mole) in absolute ethanol (64 ml, 1.08 mole) in a 1-liter round bottom flask cooled to 0° C. The flask was weighed periodically and hydrogen chloride gas bubbling was continued until the weight gain was greater than 39 g (1.08 mole). The mixture was then stoppered and stored at 0° C. for 6 days. Ether (650 mi) was then added (cold) and the mixture was stored at -30° C. for 24 hours. The resulting solid was collected on a buchner funnel, transferred quickly to a large beaker, triturated quickly with cold ether, and collected again on a buchner funnel. The solid was then dried in vacuum to give the title F compound as a free flowing white solid (95 g).

1. customhydrogen chloride gas bubbling
2. additionEther (650 mi) was then added (cold)
3. waitthe mixture was stored at -30° C. for 24 hours
4. customThe resulting solid was collected on a buchner funnel
5. customtriturated quickly with cold ether
6. customcollected again on a buchner funnel
7. customThe solid was then dried in vacuum
8. customto give the title F compound as

ORD-Eintrag

ord-f946711c2a274f2e960990d792024a36

Quelldatensatz

uspto-grants-1995_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05466704