Methanesulfonic Acid → HCID 178485753, Verbindung

HRID 1290078Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1290078
[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:50][S:51]([OH:54])(=[O:53])=[O:52]>C(OCC)(=O)C.C(O)C>[CH3:50][S:51]([OH:54])(=[O:53])=[O:52].[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

5

Edukt 2

HCID 6395Methanesulfonic AcidHCID 178485751HCID 178485751, Verbindung

Produkt 1

HCID 178485753HCID 178485753, VerbindungAusbeute 82,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

The compound (310 mg) obtained in Example 1 was dissolved in ethyl acetate (7 ml) and a solution of methanesulfonic acid (44 mg) in ethyl acetate (5 ml) and ethanol (0.25 ml) was dropwise added. After stirring at room temperature for 3 hours, crystals were collected by filtration and dried under reduced pressure to give 292 mg of the title compound as white crystals (see Table 16).

Aufarbeitung

  1. filtrationcrystals were collected by filtration
  2. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-0154a20d7b3042f2a22beff0c0920b96
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05750696

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