Hydrochloric Acid → 8-(3-Amino-2,6-dichlorobenzyloxy)-3-bromo-2-methylimidazo[1,2-a]pyridine dihydrochloride

HRID 1290170Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1290170
[Br:1][C:2]1[N:6]2[CH:7]=[CH:8][CH:9]=[C:10]([O:11][CH2:12][C:13]3[C:18]([Cl:19])=[CH:17][CH:16]=[C:15]([N+:20]([O-])=O)[C:14]=3[Cl:23])[C:5]2=[N:4][C:3]=1[CH3:24].[ClH:25]>[Fe].CO>[ClH:19].[ClH:25].[NH2:20][C:15]1[C:14]([Cl:23])=[C:13]([C:18]([Cl:19])=[CH:17][CH:16]=1)[CH2:12][O:11][C:10]1[C:5]2[N:6]([C:2]([Br:1])=[C:3]([CH3:24])[N:4]=2)[CH:7]=[CH:8][CH:9]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 117969163-Bromo-8-(2,6-dichloro-3-nitrobenzyloxy)-2-methylimidazo[1,2-a]pyridine

Produkt 1

HCID 189233178-(3-Amino-2,6-dichlorobenzyloxy)-3-bromo-2-methylimidazo[1,2-a]pyridine dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23925IronKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A suspension of 3-bromo-8-(2,6-dichloro-3-nitrobenzyloxy)-2-methylimidazo[1,2-a]pyridine (215 mg) and iron (powder, 84 mg) in a mixture of conc. hydrochloric acid (1 ml) and methanol (1 ml) was refluxed for half an hour. The cooled mixture was poured into an ice water (15 ml). The precipitates were collected and washed with water to give 8-(3-amino-2,6-dichlorobenzyloxy)-3-bromo-2-methylimidazo[1,2-a]pyridine dihydrochloride (140 mg) as an off-white solid.

Aufarbeitung

  1. temperaturewas refluxed for half an hour
  2. customThe precipitates were collected
  3. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-2bf8fdcca0864bd298dd8181c3483414
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05750699

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