Hydrochloric Acid → 3-Bromo-8-(2,6-dichloro-3-nitrobenzyloxy)-2-methylimidazo[1,2-a]pyridine hydrochloride

HRID 1290201Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1290201
[Br:1][C:2]1[N:6]2[CH:7]=[CH:8][CH:9]=[C:10]([O:11][CH2:12][C:13]3[C:18]([Cl:19])=[CH:17][CH:16]=[C:15]([N+:20]([O-:22])=[O:21])[C:14]=3[Cl:23])[C:5]2=[N:4][C:3]=1[CH3:24].Cl>C(O)C>[ClH:19].[Br:1][C:2]1[N:6]2[CH:7]=[CH:8][CH:9]=[C:10]([O:11][CH2:12][C:13]3[C:18]([Cl:19])=[CH:17][CH:16]=[C:15]([N+:20]([O-:22])=[O:21])[C:14]=3[Cl:23])[C:5]2=[N:4][C:3]=1[CH3:24]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 117969163-Bromo-8-(2,6-dichloro-3-nitrobenzyloxy)-2-methylimidazo[1,2-a]pyridine

Produkt 1

HCID 189232323-Bromo-8-(2,6-dichloro-3-nitrobenzyloxy)-2-methylimidazo[1,2-a]pyridine hydrochlorideAusbeute 161,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

To a suspension of 3-bromo-8-(2,6-dichloro-3-nitrobenzyloxy)-2-methylimidazo[1,2-a]pyridine (200 mg) in ethanol (2 ml) was added hydrogen chloride in ethanol (3.5 Mol solution, 1 ml). The solution was concentrated to half volume under reduced pressure. The separated precipitates were collected by filtration and washed with ethanol to give 3-bromo-8-(2,6-dichloro-3-nitrobenzyloxy)-2-methylimidazo[1,2-a]pyridine hydrochloride (175 mg) as an off-white solid.

Aufarbeitung

  1. concentrationThe solution was concentrated to half volume under reduced pressure
  2. customThe separated precipitates
  3. filtrationwere collected by filtration
  4. washwashed with ethanol

Quellen und Nachweise

ORD-Eintrag
ord-d4ac2012b2d24e31a6246127afc9be8d
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05750699

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