Methylamine → 2-[4-[2-[4-(4-Pyridyl)piperazin-1-yl]acetyl]phenoxy]-N-methylacetamide

HRID 1290517

Reaktionsgleichung

Reaktionsgleichung von HRID 1290517
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]([C:16]3[CH:27]=[CH:26][C:19]([O:20][CH2:21][C:22]([O:24]C)=O)=[CH:18][CH:17]=3)=[O:15])[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[CH3:28][NH2:29]>C(O)C>[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:8][CH2:9][N:10]([CH2:13][C:14]([C:16]3[CH:27]=[CH:26][C:19]([O:20][CH2:21][C:22]([NH:29][CH3:28])=[O:24])=[CH:18][CH:17]=3)=[O:15])[CH2:11][CH2:12]2)=[CH:3][CH:2]=1

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 22118604Methyl 4-[2-[4-(4-pyridyl)piperazin-1-yl]acetyl]phenoxyacetate

Produkt 1

HCID 189185792-[4-[2-[4-(4-Pyridyl)piperazin-1-yl]acetyl]phenoxy]-N-methylacetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A suspension of the product of Example 1 (100 mg) in a 33% w/v solution of methylamine in ethanol (3 ml) was stirred for 18 hours. The solid formed, after filtration and washing with a little ethyl acetate, gave the title compound, 65 mg: m.p. 169°-171° C.; NMR (d6 DMSO)δ8.14(2H,d), 8.06(1H,bq), 8.00(2H,d), 7.05(2H,d), 6.80(2H,d), 4.56(2H,s), 3.82(2H,s), 3.30(4H,t), 2.66(3H,d), 2.61(4H,t); m/e 369 (M+H)+ ; calculated for C20H24N4O3 : C, 65.2; H, 6.6; N, 15.2. found: C, 65.0; H, 6.8; N, 15.1%.

Aufarbeitung

  1. customThe solid formed
  2. filtrationafter filtration
  3. washwashing with a little ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-18a6bebac7ff486c8b0b08d2f63bad40
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05750754

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